研究方向：
1）细胞外囊泡与疾病诊疗
2）类器官细胞外囊泡转化应用
3）细胞外囊泡产业转化
研究中心主任：
刘晗 副研究员
研究中心特聘教授：
郭克迎 特聘教授 蒋成 特聘教授 利时雨 特聘教授
研究中心代表性工作：
1. Guo K, Wustoni S, Koklu A, Díaz-Galicia E, Moser M, Hama A, Alqahtani AA, Ahmad AN, Alhamlan FS, Shuaib M, Pain A, McCulloch I, Arold ST, Grünberg R, Inal S. Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors. Nature Biomedical Engineering.2021;5(7):666-677. (IF: 26.6, 1区Top)
2. Jiang, C., Wang, G X., Hein, R., Liu, N Z., Luo, X L., * & Davis, J J* (2020). Antifouling Strategies for Selective In Vitro and In Vivo Sensing. Chemical Reviews. 120, 8, 3852-3889. (IF: 55.8, 1区Top)
3. Yan S#, Jiang C#, Janzen A, Barber TR, Seger A, Sommerauer M, Davis JJ, Marek K, Hu MT, Oertel WH, Tofaris GK. Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease. JAMA Neurology. 2024;81(1):59-68. (IF: 21.3, 1区Top)
4. Yan S, Zhang W, Li X, Dutta S, Castle AR, Liu Y, Sahoo A, Lam CL, Gatford NJF, Hu MT, Li CZ, Jiang C*, Shu B*, Tofaris GK*. Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson's disease. Cell Reports Medicine. 2025;6(3):101999. (IF: 10.6, 1区Top)
5. Zheng J, Jiang X, Bai S, Lai M, Yu J, Chen M, Zhou R, Jia Y, Yan H, Liang Z, Wang D, Wu C, Liu S, Li C, Yang J*, Luo Y*, Jiang C*, Guo K*. Clinically Accurate Diagnosis of Alzheimer's Disease via Single-Molecule Bioelectronic Label-Free Profiling of Multiple Blood Extracellular Vesicle Biomarkers. Advanced Materials. 2025. e2505262. (IF: 26.8, 1区Top)
6. Li S#, Liu S#, Jiang Z#, Feng L, Gao Y, Chen Y, Xu A, Huang W*, Zhang N*, Sun H*. Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro. Signal Transduction and Targeted Therapy. 2021 Mar 2;6(1):104. (IF: 52.7, 1区Top)
7. Li S, Zheng W, Deng W, Li Z, Yang J, Zhang H, Dai Z, Su W, Yan Z, Xue W, Yun X, Mi S, Shen J, Luo X, Wang L, Wu Y, Huang W. Logic-Based Strategy for Spatiotemporal Release of Dual Extracellular Vesicles in Osteoarthritis Treatment. Advanced Science (Weinh). 2024 Jul;11(26):e2403227. (IF: 13.1, 1区Top)
8. Guangyin Zhou,# Qirong Zhou,# Ruiyang Li,# Shihao Sheng,# Qianmin Gao, Dongyang Zhou, Long Bai, Zhen Geng, Yan Hu, Hao Zhang, Xiao Chen, Jian Wang, Yingying Jing,* Ke Xu,* Han Liu,* Jiacan Su*. Synthetically engineered bacterial extracellular vesicles and IL-4-encapsulated hydrogels sequentially promote osteoporotic fracture repair. ACS Nano. 2025;19(16):16064-16083（1区Top，IF 16.0，封面文章）
9. Xiangxiang Kong,# Han Liu,#* Sumeng Chen, Zhinan Liu, Qin Chen, Xiang Li, Honggang Hu*, Jiacan Su*, Yejiao Shi*. Bioengineered bacterial extracellular vesicles for targeted delivery of an osteoclastogenesis-inhibitory peptide to alleviate osteoporosis. Journal of Controlled Release. 2025. 382, 113751.（1区，IF 11.5）
10. Sicheng Wang#, Yan Hu#, Peiran Song#, Qiushui Lin#, Xuan Tang, Qianmin Gao, Jian Wang, Dongyang Zhou, Jilong Li, Dan Huang, Long Bai, Xiao Chen, Jie Gao *, Han Liu*, Zhongmin Shi*, Jiacan Su*. Harnessing extracellular vesicles from Lactobacillus reuteri and Lactobacillus paracasei for synergistic osteoporosis therapy. Composites Part B-Engineering. 297 (2025) 112255.（1区 Top，IF 14.2）
11. Mingkai Wang #, Ruiyang Li#, Shihao Sheng#, Huijian Yang#, Xuan Tang, Jian Wang, Fuxiao Wang, Qin Zhang, Long Bai, Xiao Chen, Jie Gao*, Xiaoxiang Ren*, Han Liu*, Jiacan Su*. MOF nanozyme mediated bacterial metabolic regulation to intervene MRSA antibiotic tolerance for enhanced antimicrobial efficacy. Nano Today 63 (2025) 102753.（2区Top，IF 10.9）
12. Mingkai Wang#, Ruiyang Li#, Shihao Sheng#, Zhenglin Dong#, Long Bai, Xiuhui Wang, Jianhua Wang, Yuxiao Lai, Xiao Chen, Xiao Chen, Jie Gao*, Chongru He*, Han Liu*, Jiacan Su*. Combination therapy using intestinal organoids and their extracellular vesicles for inflammatory bowel disease complicated with osteoporosis. Journal of Orthopaedic Translation 53 (2025) 26-36. （1区，IF 7.8）
13. Han Liu#, Ting Cheng#, Guangfeng Li#, Zhidao Xia, Chenglong Wang*, Ke Xu*, Jiacan Su*. Organoid‐tissue extracellular vesicles. Interdisciplinary Medicine. 2025;e20250006. (IF 13.6)
14. Ruina Han#, Dongyang Zhou#, Ning Ji#, Zhifeng Yin#, Jian Wang, Qin Zhang, Hao Zhang, Jinlong Liu, Xinru Liu*, Han Liu*, Qinglin Han*, Jiacan Su*. Folic acid-modified ginger-derived extracellular vesicles for targeted treatment of rheumatoid arthritis by remodeling immune microenvironment via the PI3K-AKT pathway. Journal of Nanobiotechnology. 23, 41 (2025). （1区 Top，IF 12.6）
15. Han Liu#, Peiran Song#, Hao Zhang#, Fengjin Zhoue#, Ning Ji, Mingkai Wang, Guangyin Zhou, Ruina Han, Xinru Liu, Weizong Weng, Haoqi Tan, Sicheng Wang*, Lei Zheng*, Yingying Jing*, Jiacan Su*. Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 ameliorate osteoporosis. Synthetic biology-based bacterial extracellular vesicles displaying BMP-2 and CXCR4 to ameliorate osteoporosis. Journal of Extracellular Vesicles. 2024;13:e12429（1区 Top，IF 14.5，ESI高被引）
16. Han Liu#, Ruiyang Li#, Huijian Yang#, Bo Situ*, Guangchao Wang*, Ke Xu*, Jiacan Su*. Extracellular vesicles in gut-bone axis: Novel insights and therapeutic opportunities for osteoporosis. Small Science. 2024. 2400474.（IF 8.3，封面文章）
17. Guangyin Zhou#, Ruiyang Li#, Shihao Sheng#, Jingtao Huang#, Fengjin Zhou*, Yan Wei*, Han Liu*, Jiacan Su*. Organoids and organoid extracellular vesicles-based disease treatment strategies. Journal of Nanobiotechnology. 2024. doi:10.1186/s12951-024-02917-3.（1区 Top，IF 12.6）
18. Han Liu#, Jiacan Su*. Artificial intelligence-enabled studies on organoid and organoid extracellular vesicles. Biomaterials Translational. 2024, 5(2), 93-94.
19. Yuan-Wei Zhang#, Pei-Ran Song#, Si-Cheng Wang#, Han Liu*, Zhong-Min Shi*, Jia-Can Su*. Diets intervene osteoporosis via gut-bone axis. Gut Microbes. 2024. 16:1, 229543（医学1区 Top，IF 11.0）
20. Mingkai Wang#, Yan Wu#, Guangfeng Li#, Qiushui Lin#, Wencai Zhang*, Han Liu*, Jiacan Su*. Articular cartilage repair biomaterials: strategies and applications. Materials Today Bio 24 (2024) 100948.（1区，IF 10.2，ESI高被引）
21. Ruina Han#, Yan Wu#, Yafei Han#, Xiangfei Liu*, Han Liu*, Jiacan Su*. Engineered plant extracellular vesicles for autoimmune diseases therapy. Nano Research. 2024. 17, 2857-2873.（1区 Top，IF 9.0，年度最佳封面文章）
22. Yan Wu#, Peiran Song#, Miaomiao Wang#, Han Liu*, Yingying Jing*, Jiacan Su*. Extracellular derivatives for bone metabolism. Journal of Advanced Research. 2024.66. 329-347.（1区 Top，IF 13.0）
23. Han Liu#, Yan Wu#, Fuxiao Wang#, Sicheng Wang#, Ning Ji, Mingkai Wang, Guangyin Zhou, Ruina Han, Xinru Liu, Weizong Weng, Wencai Zhang, Haoqi Tan, Yingying Jing, Wencai Zhang*, Hao Zhang*, Zhongmin Shi*, Jiacan Su*. Bone-targeted engineered bacterial extracellular vesicles delivering miRNA to treat osteoporosis. Composites Part B-Engineering. 2023. 267, 11047.（1区 Top，IF 14.2）
24. Han Liu#, Hao Zhang#, Sicheng Wang#, Jin Cui, Weizong Weng, Xinru Liu, Hua Tang, Yan Hu, Xiaoqun Li, Kun Zhang, Fengjin Zhou*, Yingying Jing*, Jiacan Su*. Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis. Composites Part B-Engineering. 2023. 225, 110610（1区Top，IF 14.2）
25. Han Liu#, Jinru Sun#, Mingkai Wang#, Sicheng Wang*, Jiacan Su*, Can Xu*. Intestinal organoids and organoids extracellular vesicles for inflammatory bowel disease treatment. Chemical Engineering Journal. 2023. 465, 142842.（1区 Top，IF 13.2）
26. Han Liu, Jiacan Su*. Organoid and organoid extracellular vesicles for osteoporotic fractures therapy: current status and future perspectives. Interdisciplinary Medicine. 2023. e20230011.（IF 13.6）
27. Han Liu#, Jiacan Su*. Organoid extracellular vesicle-based therapeutic strategies for bone therapy. Biomaterials Translational. 2023, 4(4), 199-212. （封面文章）
28. Ning Ji#, Fuxiao Wang#, Miaomiao Wang#, Wencai Zhang*, Han Liu*, Jiacan Su*. Engineered bacterial extracellular vesicles for central nervous system diseases. Journal of Controlled Release. 2023.364 (2023) 46-60.（1区，IF 11.5）
29. Shuming Sun#, Han Liu#, Yan Hu, Yanpeng Wang, Mingri Zhao, Yijun Yuan, Yafei Han, Yingying Jing, Jin Cui*, Xiaoxiang Ren*, Xiao Chen*, Jiacan Su*. Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle. Bioactive Materials. 2023, 3, 166-178.（1区 Top，IF：20.3，封面文章，ESI高被引）
30. Han Liu#, Qin Zhang#, Sicheng Wang#, Weizong Weng*, Yingying Jing*, Jiacan Su*. Bacterial extracellular vesicles as bioactive nanocarriers for drug delivery: Advances and perspectives. Bioactive Materials. 2022. 14, 169-181（1区Top，IF：20.3，ESI高被引）
31. Han Liu#, Mengmeng Li#, Tao Zhang# , Xinru Liu*，Hao Zhang*, Zhen Geng*，Jiacan Su*. Engineered bacterial extracellular vesicles for osteoporosis therapy. Chemical Engineering Journal. 2022. 450 (4), 13809（1区 Top，IF 13.2）
32. Han Liu#, Hao Zhang#, YaFei Han#, Yan Hu*, Zhen Geng*, Jiacan Su*. Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy. Theranostics. 2022; 12(15): 6576-6594.（1区 Top，IF 13.3，封面文章）
33. Han Liu#, Zhen Geng#, Jiacan Su*. Engineered mammalian and bacterial extracellular vesicles as promising nanocarriers for targeted therapy. Extracellular Vesicles and Circulating Nucleic Acids. 2022, 3, 63-86.（封面文章，IF 4.8）
34. Han Liu, Yu Wang, Yehua Hou, Zhimin Li*. Fitness of chassis cells and metabolic pathways for L-cysteine overproduction in Escherichia coli. Journal of Agricultural and Food Chemistry. 2020. 68, 50, 14928-14937.（1区 Top, IF 6.2）
35. Han Liu, Yehua Hou, Yu Wang, Zhimin Li*. Enhancement of sulfur conversion rate in the production of L-cysteine by engineering Escherichia coli. Journal of Agricultural and Food Chemistry. 2020. 68, 250-257.（1区 区 Top, IF 6.2）
36. Xu Xue#, Han Liu#, Sicheng Wang#, Yan Hu, Biaotong Huang, Mengmeng Li, Jie Gao*, Xiuhui Wang*, Jiacan Su*. Neutrophil-erythrocyte hybrid membrane-coated hollow copper sulfide nanoparticles for targeted and photothermal/anti-inflammatory therapy of osteoarthritis. Composites Part B-Engineering. 2022, 237, 109855.（1区 Top，IF：14.2，ESI高被引）
37. Xu Xue#, Hao Zhang#, Han Liu#, Sicheng Wang#, Jiadong Li, Qirong Zhou, Xiao Chen, Xiaoxiang Ren, Yingying Jing, Yonghui Deng*, Zhen Geng*, Xiuhui Wang*, Jiacan Su*. Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration. Advanced Functional Materials. 2022, 2202470, 1-14.（1区 Top，IF 19.0，ESI高被引）
38. Yan Hu#, Jin Cui#,Han Liu#, Sicheng Wang, Qirong Zhou, Hao Zhang, Jiawei Guo, Liehu Cao, Xiao Chen*, Ke Xu*, Jiacan Su*. Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis. RMD Open. 2022, 8, e002314.（2区，IF 4.7）
39. Xiaoxiang Ren#, Han Liu#, Xianmin Wu#, Weizong Weng*, Xiuhui Wang*, Jiacan Su*. Reactive Oxygen Species (ROS)-Responsive Biomaterials for the Treatment of Bone-Related Diseases. Frontiers in Bioengineering and Biotechnology. 2022, 9 (1381). （3区，IF：4.8，ESI高被引）
40. Minghui Wen#, Jingyu Wang#, Zihao Ou#, Guangjun Nie, Ye Chen, Min Li, Zhiwei Wu, Sidong Xiong, Hongwei Zhou, Zifeng Yang, Gang Long, Jiacan Su, Han Liu, Yingying Jing, Zhenke Wen, Yuxuan Fu, Tieli Zhou, Hui Xie, Wenda Guan, Zhang Wang, Juan Wang, Xunxun Chen, Linglei Jiang, Xiaolin Qin, Yicong Xue, Mei Huang, Xinyue Huang, Ruoru Pan, Haojun Zhen, Yuqi Du, Qianbei Li, Xixin Huang, Yuanyuan Wu, Pingping Wang, Kening Zhao, Bo Situ*, Xiumei Hu*, Lei Zheng*. Bacterial extracellular vesicles: A position paper by the microbial vesicles task force of the Chinese society for extracellular vesicles. Interdisciplinary Medicine. 2023;1: e20230017.（细菌外囊泡专家共识，IF 13.6）
